ABSTRACT
The varied forms of leprosy form a clinical and immunological spectrum which offers extraordinary possibilities for insight into immunoregulatory mechanisms in man. At one pole, tuberculoid leprosy, patients develop high levels of cell-mediated immunity which ultimately results in killing of bacilli in the tissues, albeit often with damage to nerves. At the lepromatous pole, patients exhibit selective immunological unresponsiveness to antigens of Mycobacterium leprae. Even though all currently known protein species of Mycobacterium leprae and BCG are cross-reactive, lepromatous patients unreactive to Mycobacterium leprae antigens frequently respond strongly to tuberculin. In vitro experiments suggest the existence of lepromin-induced suppressor activity, mediated by both monocytes and Τ cells. The Τ suppressor cells have the T8 phenotype of which 50% express the activation markers, Ia and FcR. The one unique species of antigen of the leprosy bacillus is a phenolic glycolipid, and it appears that the Ts cells largely recognize the terminal trisaccharide of this unique antigen. Depletion of Ts cells restores in vitro reactivity of lymphocytes to lepromin in a portion of lepromatous patients, and addition of IL-2 containing supernatants partially restores responsiveness to Mycobacterium leprae antigens. Vaccination of lepromatous patients with a mixture of Mycobacterium leprae and live BCG restores cell-mediated immunity in the majority of lepromatous patients, and concomitantly reduces the in vitro suppressor activity and number of activated T8 cells. These experiments suggest the existence of stage-of-disease related suppressor cells in leprosy which appear to block the responsiveness of TH capable of responding to either specific or cross-reactive mycobacterial antigens. The mode of action of these Ts appears to be the inhibition of production of IL-2 and other lymphokines. Successful immunotherapeutic vaccination appears to overcome this block in the majority of patients.
ABSTRACT
Se destacan los aspectos por los cuales la lepra sigue siendo un problema y un desafió, y las razones para considerar y explorar varios tipos de vacunas. Se parte de 2 premisas: la inducción de inmunidad mediada por células otorgará protección contra la invección y se puede inducir inmunidad mediada por células específicas inmunizando com M. leprae muerto u otras microbacterias. Son presentados 2 enfoques respecto a la vacunación: inmunoprofilaxis e inmunoterapia. Problemas epidemiológicos, duración de la sensibilización, especificidad y variables desconocidas son presentados como inherentes a la vacuna contra lepra. Se marcan futuras direciones a seguir respecto del tema (seroepidemiologia, antígenos para vacunas y vacunas microbacterianas)